Bothrojaracin

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August undefined, 2024

WebMar 1, 2002 · Bothrojaracin (BJC) is a 27 kDa snake venom protein from Bothrops jararaca that has been characterized as a potent ligand (KD = 75 nM) of human prothrombin (Monteiro RQ, Bock PE, Bianconi ML,... WebMay 9, 2005 · Bothrojaracin is a snake venom-derived protein that binds to thrombin exosites 1 and 2. Complex formation impairs several exosite-dependent activities of thrombin including fibrinogen cleavage and platelet activation. Bothrojaracin also interacts with proexosite 1 on prothrombin thus decreasing the zymogen activation by the …

Identification of Bothrojaracin-like proteins in snake venoms from

WebO Scribd é o maior site social de leitura e publicação do mundo. WebBothrojaracin is a potent and selective thrombin inhibitor that has been isolated from the venom of Bothrops jararaca. It does not interact with the catalytic site of the enzyme but binds to both ani... ghana head wrap

Exploiting the antithrombotic effect of the (pro)thrombin …

Web× Close. The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. WebJan 1, 2010 · This review focuses on bothrojaracin, which is snaclec molecule, either bind to thrombin, inhibiting its biological activities, such as clotting of fibrinogen, platelet … WebIndeed, bothrojaracin and hirugen do not decrease the amidolytic activity of thrombin. However, triabin partially suppresses this activity. Since this effect is low compared to its inhibitory activity on fibrinogen clotting and platelet aggregation, it is conceivable that it binds only to the anion-binding exosite. christy gomez

Characterization of bothrojaracin interaction with …

Subunit dissociation, unfolding, and inactivation of bothrojaracin, …

WebJan 1, 1992 · Allosteric changes of thrombin catalytic site induced by interaction of bothrojaracin with anion-binding exosites I and II. Monteiro RQ, Rapôso JG, Wisner A, Guimarães JA, Bon C, Zingali RB. Biochem Biophys Res Commun, 262(3):819-822, 01 Sep 1999 Cited by: 17 articles PMID: 10471408 WebBothrojaracin binds to the thrombin precursor, prothrombin. This interaction is calcium-independent and is prevented by heparin, suggesting that it is mediated by exosite 2. … ghana healthcare providers levelsWebOct 1, 1999 · Bothrojaracin, a 27 kDa protein isolated from Bothrops jararaca venom, forms a non-covalent complex with thrombin, thus blocking its activity. We have previously identified a bothrojaracin-like protein in B. alternatus venom [Castro, H.C., Dutra, D.L.S., Oliveira-Carvalho, A.L., Zingali, R.B., 1998. ghana health care system overview

"WebBothrojaracin is a specific inhibitor of thrombin-induced platelet aggregation and secretion, it prolongs fibrinogen clotting time by competitively inhibiting the binding of α-thrombin to … " - Bothrojaracin

Bothrojaracin

Batrachotoxin - an overview ScienceDirect Topics

WebToxin Uses. Batrachotoxin is an important research tool in pharmacology because of its action of holding voltage-gated sodium channels open as well as its specific effects at … WebFeb 1, 2005 · Bothrojaracin (BJC) is a selective and potent thrombin inhibitor (KD = 0.6 nM) which also binds to prothrombin on proexosite I (KD = 175 nM). Incubation of BJC with human or rat plasma produced a ...

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WebDec 1, 1998 · Bothroalternin (MW 27 kDa), a new member of the family of C-type lectins is a thrombin inhibitor which was purified from pooled B. alternatus venom by affinity chromatography on PPACK-thrombin-Sepharose, followed by size exclusion and reverse-phase on HPLC columns. WebSep 1, 2016 · Bothrojaracin is a 27 kDa C-type lectin-like protein from Bothrops jararaca snake venom. It behaves as a potent thrombin inhibitor upon high-affinity binding to …

WebSummary Bothrojaracin (BJC) is a 27 kDa snake venom protein from Bothrops jararaca that has been characterized as a potent ligand (K D = 75 nM) of human prothrombin (Monteiro RQ, Bock PE, Bianconi ML, Zingali RB, Protein Sci 2001; 10: 1897-904). BJC binds to the partially exposed anion-binding exosite I (proexosite I) forming a stable 1:1, … WebOct 12, 1993 · Bothrojaracin, a new thrombin inhibitor isolated from Bothrops jararaca venom: Characterization and mechanism of thrombin inhibition Russolina B. Zingali Martine Jandrot-Perrus Marie Claude Guillin Cassian Bon Cite This:Biochemistry 1993324010794-10802 Publication Date: October 12, 1993 …

WebBothrojaracin binds to the thrombin precursor, prothrombin. This interaction is calcium-independent and is prevented by heparin, suggesting that it is mediated by exosite 2. … WebDec 31, 2008 · Bothrojaracin (BJC) is a 27-kD snake venom protein from Bothrops jararaca that has been characterized as a potent thrombin inhibitor. BJC binds to exosites I and II, with a dissociation constant...

WebOct 1, 2000 · Here, we show that bothrojaracin specifically interacts with prothrombin in human plasma. It is an effective anticoagulant after activation of the intrinsic pathway of …

WebA) Tripozo provides train alternates and IRCTC ticket confirmation prediction to assist you to get confirm IRCTC tickets online. In addition, information like Live Train Status, Historical … ghana health declaration form online freeWebOct 12, 1993 · Bothrojaracin, a new thrombin inhibitor isolated from Bothrops jararaca venom: Characterization and mechanism of thrombin inhibition Russolina B. Zingali … ghana headwrapsWebJan 21, 2003 · Here, bothrojaracin (BJC), a CLP from Bothrops jararaca venom that is also a thrombin inhibitor, has been used as a model to study the subunit dissociation and unfolding of CLPs from snake venom. Dithiothreitol (DTT) up to 10 mM produces minor effects on the tertiary structure and activity of BJC. christy girl clothingWebBothrojaracin (BJC) is a potent and highly specific thrombin inhibitor isolated from the venom of the jararaca snake common to Brazil (Bothrops jararaca) (Zingali et al. 1993). BJC is a 27-kD disulfide-linked heterodimer that belongs to the C-type (Ca2+-dependent) lectin-like related protein family (Arocas et al. 1997). ghana healthcare systemWebFeb 1, 2003 · Here, bothrojaracin (BJC), a CLP from Bothrops jararaca venom that is also a thrombin inhibitor, has been used as a model to study the subunit dissociation and unfolding of CLPs from snake venom.... christy goodmanWebSep 7, 1999 · Bothrojaracin, a 27-kDa C-type lectin from Bothrops jararaca venom, is a selective and potent thrombin inhibitor (K(d) = 0.6 nM) which interacts with the two thrombin anion-binding exosites (I and II) but not with its catalytic site. In the present study, we analyzed the allosteric effects produced … ghana health declaration form 2022WebFeb 1, 2002 · Bothrojaracin (BJC) is a 27 kDa snake venom protein from Bothrops jararaca that has been characterized as a potent ligand (KD = 75 nM) of human prothrombin (Monteiro RQ, Bock PE, Bianconi ML, Zingali RB, Protein Sci 2001; 10: 1897-904). BJC binds to the partially exposed anion-binding exosite I (proexosite I) forming a stable 1:1, … christy goodwin