Cisplatin cystenyl glycine conjugate
WebCisplatin (24 mg/kg body weight) was given by a single intraperitoneal injection. Mice were killed at day 1 or day 3 after cisplatin administration, blood and kidney samples were harvested for further analysis. Renal ischemia-reperfusion was induced in mice as described previously [ 21, 22 ]. WebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. National Institutes of Health. Department of Health and Human Services.
Cisplatin cystenyl glycine conjugate
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WebMei Deng is a academic researcher from University of Virginia. The author has contributed to research in topic(s): Nephrotoxicity & Conjugate. The author has an hindex of 3, co-authored 3 publication(s) receiving 322 citation(s). Previous affiliations of Mei Deng include Veterans Health Administration. WebCisplatin is nephrotoxic. The mechanism underlying this organ-specific toxicity is unknown. We hypothesize that cisplatin is metabolized via a γ -glutamyl transpeptidase (GGT) and cysteine S -conjugate β -lyase-dependent pathway that has been shown to activate several haloalkenes to nephrotoxins.
WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … WebCisplatin eligibility criteria are defined for patients with metastatic bladder cancer by the Galsky criteria, which include creatinine clearance ≥60 ml/min. However, consensus is …
http://nopr.niscair.res.in/bitstream/123456789/12869/1/IJEB%2049(10)%20791-794.pdf WebSep 15, 2024 · Cisplatin forms a Pt-GSH-conjugate in the liver and then reaches the kidneys, which is cleaved by GGT produces cysteinyl-glycine-conjugate, followed by the production of a cysteine-conjugate by aminopeptidases on the …
WebCysteine Conjugate The S-cysteine conjugate of atrazine can rearrange to form an N-cysteine conjugate, and through a deamination process can form a postulated …
WebJan 30, 2024 · Cisplatin (CP) is a broad-spectrum antineoplastic agent, used to treat many different types of malignancies due to its high efficacy and low cost. ... The resulting GSH-conjugates are cleaved into a cysteinyl-glycine-conjugate by gamma glutamyltranspeptidase which is localized on the surface of the kidney proximal tubule … how many lines of symmetry triangle haveWebJun 1, 2003 · Abstract. Previous studies have shown that cisplatin requires metabolic activation to become nephrotoxic. The activation is proposed to be via the … how many lines on a music staffWebThe first step is the conjugation to glutathione, followed by the cleavage by GGT to a cysteinyl-glycine conjugate, the cleavage by aminopeptidase to a cysteine S … how many lines on a hockey teamWebSep 8, 2024 · Cisplatin Glutathione conjugated cisplatin can be metabolized to a cysteinyl-glycine-conjugate, to a cysteine conjugate, and finally to a reactive thiol that is highly nephrotoxic . Alternatively, it is thought that glutathione conjugation, mediated by GSTA1, is a detoxification pathway responsible for cisplatin resistance in solid tumors ... how many lines on a basketballWebwww.ncbi.nlm.nih.gov how are bronze sculptures madeWebThis hypothesis was tested by pre-treating C57BL/6j mice with suramin prior to cisplatin. Our data indicates that suramin protects the kidney from injury by decreasing cisplatin-induced decreases in kidney function. Renal histology indicated that suramin significantly protected from cisplatin-induced AKI. Data indicate that suramin how many lines on a covid testWebMay 1, 2003 · Cisplatin cytotoxicity was judged by its antiproliferative action. Incubations with GSH were performed in the presence and in the absence of the dipeptide GlyGly (20 mM), added as an acceptor for the transpeptidation reaction [15] to replace the physiological acceptor cystine [18]. how are brown dwarfs made