WebMay 4, 2024 · Each complex consists of an enzyme called a kinase (CDC7 or CDK2) and a regulatory protein (DBF4 or cyclin E). CDC7 of the CDC7–DBF4 complex activates the protein complex MCM2–MCM7 by... WebCdc7.28,30 The different behavior of Dbf4 variants lacking motif C in comparison to those encompassing point mutations within the motif could reflect that the structural integrity of the zinc-finger is somewhat stabilized in the context of the Dbf4-Cdc7 complex. This, in turn, would imply that the Dbf4-Cdc7 inter-
【标题速读】【Ncomm】【biological-sciences】【2024年】【5 …
WebMar 11, 2024 · Primary Citation of Related Structures: 6YA6, 6YA7, 6YA8. PubMed Abstract: CDC7 is an essential Ser/Thr kinase that acts upon the replicative helicase throughout the S phase of the cell cycle and is activated by DBF4. Here, we present crystal structures of a highly active human CDC7-DBF4 construct. The structures reveal a zinc … WebBackground: Cdc7-Dbf4 is a conserved serine/threonine kinase that plays an important role in initiation of DNA replication and DNA damage tolerance in eukaryotic cells. Cdc7 has … business office max depot
Cdc7 overexpression is an independent prognostic marker and a …
WebTraductions en contexte de "CAF-1" en français-anglais avec Reverso Context : Ensuite, nous avons identifiés une interaction physique entre CAF-1 et Cdc7-Dbf4. WebNov 19, 2002 · The Dbf4/Cdc7 kinase acts at the level of individual origins to promote the initiation of DNA replication. We demonstrate through both immunoprecipitation and two-hybrid assays that a domain comprising the first 296 aa of Dbf4p interacts with Orc2p and Orc3p subunits of the origin recognition complex (ORC). Given that the activation of … WebSep 1, 1994 · The Dbf4-Cdc7 kinase (DDK) is required for the activation of the origins of replication, and DDK phosphorylates Mcm2 in vitro. We find that budding yeast Cdc7 alone exists in solution as a weakly ... business office phone plans