WebOct 15, 2005 · Effects of polyethylene glycol 400 (PEG-400) following 13 weeks of gavage treatment in Fischer-344 rats Fd. Chem. Toxicol. (1995) T. Hatanaka et al. Effect of vehicle on the skin permeability of drugs: polyethylene glycol 400–water and ethanol–water binary solvents J. Contr. Release (1993) R.S. Harris et al. WebDec 15, 2013 · Due to the strong hydrophilic properties, low molecular weight PEGs, such as PEG-400, have been used in non-clinical studies to deliver poorly hydrosoluble drugs by different routes, including intraperitoneal (ip) administration (Gad …
Kollisolv® PEG 400 Solvents / Co-solvents BASF Pharma
WebTwenty-four dogs were divided into four groups: a control group receiving normal saline and three test groups receiving 4.23, 6.34, and 8.45 g/kg of PEG-400, respectively, by i.v. injection once a day for 30 days. The repeated-dose toxicity of PEG-400 was assessed. Toxicokinetic parameters of PEG-400 in dogs were estimated on days 1 and 30. WebDec 1, 2024 · Polyethylene glycol 400 (PEG 400) is generally considered to be among the safest organic co-solvents and are very commonly used in preclinical in vivo … msvcr70 dll windows10
Polyethylene glycols (PEGs) for Pharmaceutical… BASF …
WebDec 1, 2024 · Vehicle toxicity and tolerability data are not readily available for a number of combination vehicles therefore, an i.v. tolerability studies was planned in rats with 5% v/v Pharmasolve (NMP), 45% v/v Propylene glycol (PG) and 50% v/v Polyethylene glycol (PEG) 400 combination, at dose volume of 0.5, 1, 2 and 5 mL/kg body weight for 28 days. The ... WebPoly (ethylene glycol) (PEG) has been used as a coating agent for the synthesis and in vitro safety assessment of magnetic bacterial cellulose (MBC) pellicles, performed on porcine aortic smooth muscle cells (PAOSMC). PEG provides a compatible surface for cell culture, since uncoated iron oxide NPs are considered cytotoxic to cells. [ 1] WebMay 12, 2024 · A publicly available article also appearing in PubMed about Polyethylene Glycol. ... Acidosis has been reported in literature and case reports with the intravenous administration of drugs utilizing PEG as a vehicle and repeated topical dermal exposure of PEG in burn patients. ... which contained PEG-400 in propylene glycol with 2% benzyl ... msvcr71.dll download windows 10