Phosphate translocase
WebWe directly observed the movement of purified FtsK, an Escherichia coli translocase, on single DNA molecules. Learn more about Carlos Bustamante's work experience, education, connections & more ... WebJan 17, 1997 · Recently, chlorogenic acid was identified as a specific inhibitor of the glucose-6-phosphate translocase component (Gl-6-P translocase) of this enzyme system …
Phosphate translocase
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WebSLC37A4, also known as glucose-6-phosphate translocase (G6PT), is the more extensively studied isoform, and is a member of the multicomponent glucose-6-phosphatase system (G6Pase-system). In the liver and kidney, the activity of this complex is required to maintain blood glucose homeostasis ( Bartoloni and Antonarakis, 2004 ). WebAdding a lipophilic chain at position 1 resulted in derivatives that could be taken up by hepatocytes and enhanced the inhibitory activity on hepatic glucose-6-phosphate translocase [9,10,11]. This enzyme catalyzes the final step in glycogenolytic and gluconeogenic pathways to liberate free glucose into the circulation, and inhibitors of this ...
WebDec 27, 2024 · Lysine residues are essential in regulating enzymatic activity and the spatial structure maintenance of mitochondrial proteins and functional complexes. The most important parts of the mitochondrial permeability transition pore are F1F0 ATPase, the adenine nucleotide translocase (ANT), and the inorganic phosphate cotransporter. The … WebThe phosphate translocase can operate in an antiport mode, transferring hydroxide ion (OH −) out of the matrix in response to the pH component of the gradient: In this case, there …
WebGlucose-6-phosphatase is an enzyme located on the inner membrane of the endoplasmic reticulum. The catalytic unit is associated with a calcium binding protein, and three transport proteins (T1, T2, T3) that facilitate movement of glucose-6-phosphate (G6P), phosphate, and glucose (respectively) into and out of the enzyme. Pathophysiology [ edit] WebSep 21, 2024 · Glycogen storage disease type Ib (GSDIb) is an autosomal recessive disorder caused by mutations of SLC37A4 gene, which encodes glucose 6-phosphate translocase (G6PT). Malfunction of G6PT leads to excessive fat and glycogen in liver, kidney, and intestinal mucosa.
WebJan 17, 1997 · It is responsible for the formation of endogenous glucose originating from gluconeogenesis and glycogenolysis. Recently, chlorogenic acid was identified as a specific inhibitor of the glucose-6-phosphate translocase component (Gl-6-P translocase) of this enzyme system in microsomes of rat liver.
WebNM_001164277.2(SLC37A4):c.148+1G>A AND Glucose-6-phosphate transport defect. Clinical significance: Pathogenic (Last evaluated: Sep 4, 2024) Review status: ... dicks going going gone olatheWebGlycogen storage diseases type I (GSD I) are a group of metabolic disorders arising from a defect in a component of this enzymatic system, i.e. the glucose-6-phosphate hydrolase (GSD Ia), the glucose-6-phosphate translocase (GSD Ib) and possibly also the translocases for inorganic phosphate (GSD Ic) or glucose (GSD Id). dicks going going gone olathe ksWebNov 1, 2001 · A class of chlorogenic acid derivatives, which potently and specifically inhibit G6Pase activity by blocking the translocase of the G6Pase complex, has recently been developed and eventually will be aimed at treating hyperglycemic conditions in type 2 diabetes (20,21,22).Infusion of members of this class of compounds in anesthetized rats … dicks going going gone orland park ilWebThe SLC25A3 gene located at 12q23.1 encodes the mitochondrial phosphate carrier, a transporter that transports inorganic phosphate into the mitochondrial matrix for the … dicks gold scorecardWebThe phosphate is carried by a histidine residue in EI and HPr but usually by a cysteine, in most EIIB domains. In the resting state, that is, in the absence of a PTS sugar, the PTS … citrus county medicaid doctorsWebMar 15, 2002 · The authors draw two interesting conclusions. First, the presence in the bacterium of a mammalian-type glucose-6-phosphate translocase and its involvement in the movement of sugars from the cytosol into the bacterium suggest an example of adaptation to a parasitic life style by mimicry of eukaryotic cell functions.This may provide us with … citrus county map with citiesWebSep 15, 2001 · With glucose 6-phosphate translocase inhibited by S4048, oleate increased intracellular glucose 6-phosphate (3-fold) and net glycogen production (1.5-fold), without a major change in GSa activity. It is concluded that glucose cycling in hepatocytes prevents the net accumulation of glycogen from glucose. dicks going going gone store